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What Is an Allergy.....? Your immune system’s job is to protect you from bacteria and viruses. If you have allergies, though, part of your immune system works too hard. It may attack harmless substances -- like cat dander or pollen -- in your nose, lungs, eyes, and under your skin. When your body meets an allergen, it makes chemicals called IgE antibodies. They cause the release of chemicals like histamine, which cause swelling and inflammation. This creates familiar symptoms like a runny nose, itchy eyes, and sneezing as your body tries to remove the allergen.