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Low Libido Factor No. 1: Physical Health A physical exam is needed because medical conditions like arthritis, diabetes, heart disease, and other chronic diseases can lead to a decreased libido in men or women One patient with the digestive disorder celiac disease felt discomfort during sex because of pressure on her inflamed colon. Sex-specific problems, Any vaginal pain during sex is both abnormal and can affect libido, and should be evaluated by your doctor. Female patients will be asked about any vaginal discharge, which could be a sign of infection that may, in turn, cause low libido. Antidepressants, birth control pills, and even antihistamines can cause low libido.