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Fellowship in Sexology and Psychosexual Counseling. For More Info WhatsApp- 9604715783/9359863878. As arterioles and the muscles relax, lacunar spaces are filled with blood, increasing the pressure on the veins and occluding the venous return and causing the penis to become erect. If there is no further sexual stimulation, cGMP is metabolized by Phosphodiesterase 5 (PDE5) resulting in loss of erection.