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Low Libido Factor No. 3: Hormone Levels Research has found that men who have higher free testosterone levels (the amount of testosterone that’s circulating in the blood) have a higher sex drive. free testosterone has a significant impact on both sex drive and erectile function. Hormone levels in women, especially when they decline during menopause, are notorious for wreaking havoc on sex drive. Lower estrogen levels after menopause in and of themselves can cause dryness and vaginal pain, which can lead to low libido. also asks her patients if they’re experiencing hot flashes and sleep problems due to menopause. If so, the resulting chronic fatigue could be the root cause of low libido. blood tests to check a patient’s levels of estrogen, progesterone, testosterone.